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Proteases or proteinases represent one of the most versatile classes of enzymes; play a central role in all organisms including protein turnover and the degradation of mis-folded proteins, as well as gene regulation. Proteases are recognized as important virulent factors in most of the pathogenic microorganisms and their inhibition has represented a successful therapeutic approach to treat the infectious diseases. Proteases of Mycobacterium tuberculosis have been recognized as important regulators of host inflammation and cellular response in various infections. Information on the central role of proteolytic  enzymes has been accumulating,  but there is still a lack of systematic knowledge of protease throughout the bacterial kingdom. For example, there is little information regarding the role of proteolysis and the involvement of proteases in the pathogenesis of tuberculosis.

Our effort is to explore proteases of   Mycobacterium tuberculosis (MTB ) and Non Tuberculous Mycobacteria (NTM) at gene and protein level. MycoProtease-DB is an online MS SQL and CGI-PERL driven relational database that domiciles protease information of Mycobacterium tuberculosis (MTB) complex and Nontuberculous Mycobacteria (NTM), whose complete genome sequence is available. Our effort is to provide comprehensive information on proteases of 5 strains of Mycobacterium tuberculosis (H37Rv, H37Ra, CDC1551, F11 and KZN 1435), 3 strains of Mycobacterium bovis (AF2122/97, BCG Pasteur 1173P2 and BCG Tokyo 172) and 4 strains of NTM (Mycobacterium avium 104, Mycobacterium smegmatis MC2 155, Mycobacterium avium paratuberculosis K-10 and Nocardia farcinica IFM 10152) at gene, protein and structural level. MycoProtease-DB currently hosts 1324 proteases, which include 906 proteases from MTB complex with 237distinct proteases & 418 from NTM with 404 distinct proteases. Flexible database design and easy expandability & retrieval of information are the main features of MycoProtease-DB. All the data were validated with various online resources and published literatures for reliable serving as comprehensive resources of various Mycobacterial proteases.


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Since November, 2012
Bioinformatics Centre
Jamnalal Bajaj Tropical Disease Research Centre
Mahatma Gandhi Institute of Medical Sciences, Sevagram - 442 102